科研成果
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2018年度中心科研成果

发布时间:2018年12月31日 15:08      来源:      点击:

一、承担科研任务及经费

序号

项目/课题名称

文号

负责人

起止时间

经费(万元)

1

国自然/基于"脂-胰-骨"相关性探索黄芪散治疗糖尿病性骨质疏松的机制

81473439

李卫民

2015-1至2018-12

66

2

国自然/黄连-吴茱萸药对改变肠道菌群结构与抗溃疡性结肠炎作用的相关性及其机制研究

81473540

廖琼峰

2015-1至2018-12

75

3

国自然/五味子经ERK/P38-Nrf2通路调节内源性抗氧化基因与转运体及配伍环孢素A的减毒机制研究

81473582

于洋

2015-1至2018-12

66

4

国自然/姜黄素协同Glu-GNPs对乳腺癌干细胞放射增敏作用及其机制研究

81503301

胡晨霞

2016-1至2018-12

18

5

国自然/新型白术内酯促骨髓间充质干细胞向软骨分化的网络共激活机制

81573558

李熙灿

2016-1至2019-12

57

6

国自然/基于AMPK/SREBP-1c信号通路研究古方黄芪散有效部位群改善肝脏胰岛素抵抗的调控机制

81503375

王春怡

2016-1至2018-12

18

7

国自然/补阳还五汤促进缺血性脑中风后康复“生新”的药效物质基础及其作用机制研究

81573872

王利胜

2016-1至2019-12

59

8

国自然/亚硫酸氢钠穿心莲内酯抗紫外线所致皮肤光老化过程中对Nrf2与NF-κB平衡体系的调节机制研究

81503318

詹雅娴

2016-1至2018-12

18

9

国自然/内皮细胞精氨酸酶活性改变在2型糖尿病血管损伤中的作用及机制研究

31600937

姚琳

2017-1至2019-12

20

10

国自然/基于Nrf2-ARE/NF-κB通路研究广东紫珠的抗炎药效物质及分子作用机制

81603269

吴爱芝

2017-1至2019-12

18

11

国自然/基于AnnexinA5-Nlrp3通路探讨三黄泻心汤对痰浊血淤型高脂血症内皮胞膜的调节作用

81603587

陈扬

2017-1至2019-12

17

12

国自然/基于体内过程和整体观研究毛冬青抗血栓的药效物质基础及协同作用机制

81673565

赵钟祥

2017-1至2020-12

57

13

国自然/基于“辛润”药性理论的当归芍药散对hiPSC技术建立肝肾亏虚型AD模型的作用机制研究

81673619

吴庆光

2017-1至2020-12

57

14

国自然/大黄牡丹汤通过短链脂肪酸抑制“鞭毛蛋白-TLR5炎症信号通路”治疗IBD的机制研究

81673668

周联

2017-1至2020-12

60

15

国自然/缩泉丸对糖尿病膀胱神经传导功能异常的修复作用及其机制研究

81673676

操红缨

2017-1至2020-12

60

16

国自然/补中益气汤经葡萄糖转运体SGLT1的调控作用治疗脾虚泄泻证的分子机制研究

81673870

施旭光

2017-1至2018-12

25

17

国自然/基于线粒体自噬调控NLRP3炎症小体活化探讨真武汤治疗慢性肾小球肾炎的作用机制

81673874

周玖瑶

2017-1至2020-12

57

18

国自然/以溶酶体Heparanase介导自噬通路为靶标设计、合成硫酸肝素类抑制剂及其逆转骨髓瘤化疗耐药研究

21772028

周文

2018.1.1-2021/12/31

64

19

国自然/黄芩汤修复微生物屏障及抑制MDP-NOD2炎症信号通路治疗炎症性肠病

81703785

罗霞

2018.1.1-2020/12/31

20

20

国自然/三子固本方活性多糖经Nrf2信号通路对TGF-β1/Smad介导的糖尿病肾病EMT的作用机制研究

81774192

于洋

2018.1.1-2021/12/31

55

21

国自然/基于肠-肝-脑轴的色氨酸代谢平衡研究疏肝理脾方药治疗抑郁症的作用机制和药效物质

81774193

王术玲

2018.1.1-2021/12/31

55

22

Angiopep-2修饰的环维黄杨星D鼻腔给药脑靶向纳米递释系统的研究

2016A020217018

于洋

2018-05-31截止

30

23

基于改善难溶性药物及其制剂口服生物利用度的新技术研究

2014A020210021

马燕

2018-05-31截止

20

24

从肠道菌群调控Th17/Treg探讨大黄牡丹汤治疗IBD的机制

2015A030313344

罗霞

2018-08-01截止

10

25

以抗氧化应激为导向的广东紫珠抗炎药效物质及作用机制研究

2015A030310491

吴爱芝

2018-08-01截止

10

26

基于AMPK/SREBP-1c信号通路研究黄芪散改善肝脏脂毒性的调控机制

2015A030313350

王春怡

2018-08-01截止

10

27

去氢木香内酯干预EMT抑制鼻咽癌转移复发的分子机制研究

2015A030310385

孙喜稳

2018-08-01截止

10

28

KBN触变凝胶剂治疗VVC有效性与安全性评价及衍生健康产品的产业化

2016B020239005

张军

2018-12-31截止

300

29

水蛭迟释微丸胶囊活性及作用机制研究

2016A020217016

林宝琴

2018-12-31截止

30

30

毛冬青三萜皂苷在血管内皮细胞的摄取转运特征和抑制炎性损伤的作用机制及物质基础研究

2016A020226031

张蕾

2018-12-31截止

30

31

基于下丘脑Orexin A/HPA轴调控的交泰丸活性成分改善胰岛素抵抗的神经内分泌作用机制研究

2017A030313752

全世建

2020-05-01截止

10

32

穿心莲总内酯含量与染色体倍性的相关性研究

2015A030302070

杜勤

2018-12-31截止

10

33

克服靶向治疗肿瘤耐药活性小分子抑制剂研究

2015A020216017

张翠仙

2018-12-31截止

50

34

基于体外雄核发育的穿心莲小孢子单倍体及纯合二倍体DH系新种质创制研究

2016A030303052

杜勤

2019-05-31截止

20

35

一种制备方法简单的刺激响应型双功能复合纳米药物制剂的研究

2016A020217017

马燕

2019-05-31截止

30

36

p38MAPK信号通路调控胰岛素抵抗骨骼肌细胞GLUT4活性与转位及小檗碱和桂皮醛配伍对其干预机制的研究

2016A030313647

全世建

2019-06-01截止

10

37

基于胞膜修复-炎症小体通路的甘草甜素早期高脂血管损伤的防治应用研究

2017A020211016

陈扬

2019-07-31截止

100

38

基于干细胞技术辨析防治骨病的中药有效成分

2017A050506043

李熙灿

2019-12-31截止

50

39

中药枳壳岭南特色“发酵蒸制”的炮制机理研究

2017A020213012

夏荃

2020-01-01截止

30

40

基于5-HT-KYN学说研究疏肝理脾法治疗抑郁症的作用机制及药效物质基础

2017A030313716

王术玲

2020-05-01截止

10

41

基于SIRT1靶点的虎金方治疗非酒精性脂肪肝的分子机制研究

2017A030313730

施旭光

2020-05-01截止

10

42

从短链脂肪酸抑制“鞭毛蛋白-TLR5炎症信号通路”探讨大黄牡丹汤治疗IBD的机制

2017A030313657

周联

2020-05-01截止

10

43

多级有序孔结构分子印迹聚合物分离银杏内酯B研究

2017A030313675

邬泉周

2020-05-01截止

10

44

第四次全国中药资源普查项目

财社[2018]43号

刘中秋、杜勤、黄海波

2019/01-2022/12

1080

45

国自然/鹰嘴豆调节肠道菌群结构与其改善慢性炎症抗2型糖尿病的相关性及其机制研究

U180310031

廖琼峰

2019/01-2022/12

60

46

中药靶向T淋巴细胞调节肿瘤代谢重塑抗肿瘤免疫的分子机制

81828013

梁丽娴

2019/01-2022/12

18

47

知母甾体皂苷生物合成关键基因的克隆及生化功能研究

81874333

段礼新

2019/01-2022/12

57

48

基于“化学-PD/PK”的附子质量标志物发现、确证及其调控毒效的分子机制研究

81874343

朱丽君

2019/01-2022/12

57

49

山奈酚的细胞核内处置调控DNA甲基转移酶抑制结肠癌分子机制及对中药山奈药效的影响

81874367

卢琳琳

2019/01-2022/12

59

50

国自然/黄芪活性成分芒柄花素靶向GSK-3β蛋白调控巨噬细胞/小胶质细胞极化抗心梗合并抑郁的作用及分子机制

81803765

程媛媛

2019/01-2021/12

21

51

国自然/从NLRP3炎症小体介导细胞焦亡探讨急性肾损伤纤维化进展的机制及丹酚酸B的干预

81803824

周园

2019/01-2021/12

21

52

国自然/双重靶向CYP11B2及盐皮质激素受体用以治疗充血性心衰

81872739

胡庆忠

2019/01-2022/12

57

53

国自然/构建“成分-效应-靶点”网络体系探讨岭南特色饮片制枳壳“存效减燥”的炮制机理

81873003

夏荃

2019/01-2022/12

56

54

国自然/姜黄素通过Hedgehog/Gli信号通路调控肿瘤干细胞干性及EMT抑制乳腺癌肺转移分子机制研究

81873052

胡晨霞

2019/01-2022/12

57

55

国自然/从miR-30介导的异体自噬探讨广藿香醇抗侵入细胞内幽门螺杆菌的机制

81873074

黄萍

2019/01-2022/12

56

56

国自然/基于鞘脂组学与质谱成像技术的补阳还五汤脑缺血损伤保护的时空特性及作用机制研究

81873227

张英丰

2019/01-2022/12

57

57

国自然/基于PI3K/Akt-SIRT1信号通路探讨补阳还五汤促进缺血性脑中风康复的药效物质基础及作用机制

81873228

王利胜

2019/01-2022/12

57

58

广东省科技基础条件建设领域立项项目/广东省中医药防治肿瘤转化药学研究重点实验室(2018年度)

2018B030322011

刘中秋

2018.09.30 -2021.09.29

300

59

广东省自然科学基金/基于系统药理学探讨真武汤治疗慢性肾小球肾炎的作用机制

2018B0303110004

周玖瑶

2017.8.1-2019.7.31

50

60

广东省自然科学基金/基于巨噬外泌体活化内皮PP2A-Nlrp3炎症通路探讨三黄泻心汤防治高脂血症血管病变的作用及作用机制

2018B030306027

陈扬

2017.8.1-2019.7.31

10

61

广东省自然科学基金/基于Cathepsin B介导NLRP3炎症小体活化研究广藿香醇特异性抗幽门螺杆菌相关炎症的作用机制

2018A030310622

连大卫

2017.8.1-2019.7.31

10

62

广东省自然科学基金/基于线粒体自噬调控NLRP3炎症小体活化探讨巴马亭治疗溃疡性结肠炎的作用机制

2018A030313326

张晓君

2017.8.1-2019.7.31

10

63

广东省自然科学基金/外泌体介导的NF-κB/NLRP3通路对IgA肾病的作用机制及真武汤干预作用

2018A030313328

周园

2017.8.1-2019.7.31

10

64

广东省自然科学基金/Nrf2对肠肝轴稳态的影响及藏方甲嘎松汤的干预作用

2018A030313515

熊天琴

2017.8.1-2019.7.31

10

65

广东省自然科学基金/五味子活性多糖经Nrf2/HO-1信号通路对环孢素A诱导肾脏EMT的作用机制研究

2018A030313447

王青

2017.8.1-2019.7.31

10

66

广东省医学科研基金/基于超临界流化包衣技术制备热敏难溶药物西罗莫司纳米颗粒研究

B2018072

李庆国

2018/01-2018/12

0

67

药学重点学科

广州市教育局

刘中秋

2019.1-2021.12

450

68

广州市科技计划项目珠江科技新星专题/基于UGT代谢酶和外排转运蛋白偶联作用的秦皮香豆素类活性成分及其衍生物体内处置特征及机理研究

7.06066E+11

朱丽君

2018/04-2021/3

30

69

广州市科技计划项目/八角瓜乳汁中强心苷类成分的分离鉴定及其强心作用机制研究

2018-1002-SF-0474

张容容

2018/04-2021/3

20

70

广州市科技计划/具有精准识别肿瘤转移标志物Heparanase硫酸肝素类糖芯片的研究

201804010325

周文

2018/04-2021/3

20

71

学科研究重大项目/结肠癌的表观遗传学发生机制及中药干预作用

A1-AFD018181A16

刘中秋

2018/04-2021/3

80

72

学科研究重大项目/中医临床防治心血管疾病常用岭南特色药材的中药学基础研究

A1-AFD018181A36

赵钟祥

2018/04-2021/3

20

73

青年创新人才项目AP2/ERF转录因子调控丹参酮合成研究

E1-KFD015181K31

季爱加

2018/1-2019/12

5

二、发表专利

序号

专利名称

专利授权号

获准国别

完成人

类型

类别

1

一种两面针再生苗的组培培养基和培养方法

ZL 2016 1 1044473.7

中国

何国振,何蔚思,汤丽云

方法

合作完成—第一人

2

一种两面针愈伤组织的诱导培养基及诱导方法和应用

ZL 2016 1 1044472.2

中国

汤丽云,何蔚思,何国振

方法

合作完成—其它

3

一种治疗类风湿关节炎的药物组合物及其制备方法和应用

第3052251号

中国

王利胜

方法

独立完成

4

一种利用微生物将铁冬青酸转化为毛冬青酸-A的方法

ZL 201510864959.4

中国

赵钟祥,杨宝,周联,朱锦萍,王青,丘茂松,曹迪

方法

独立完成

5

一种环外双键乌苏烷型三萜皂苷类化合物及其制备方法和应用

ZL 2015 1 0953771.7

中国

刘中秋,吴鹏,周华,高慧,朱丽君,卢琳琳,王莹,戚笑笑,王立萍

方法

独立完成

6

一种齐墩果烷型三萜皂苷类化合物及其制备方法和应用

ZL 2015 1 0953703.0

中国

刘中秋,吴鹏,周华,高慧,朱丽君,卢琳琳,王莹,戚笑笑,王立萍

方法

独立完成

7

一种乌苏烷型三萜皂苷类化合物及其制备方法和应用

ZL 2015 1 0953613.1

中国

刘中秋,吴鹏,周华,高慧,朱丽君,卢琳琳,王莹,戚笑笑,王立萍

方法

独立完成

三、发表论文

序号

论文或

专著名称

作者

刊物、出版社名称

卷、期

(或章节)、页

类型

类别

1

Evaluation of the influence of Mirabilite on the absorption and pharmacokinetics of the ingredients in Dahuang-mudan decoction by a validated UPLC/Q-TOF-MS/MS method

Feifei Nong;Zhongxiang Zhao

Biomed Chromatogr,

2018 :e4423.

国外刊物

独立完成

2

Rhubarb Peony Decoction Ameliorates Ulcerative Colitis in Mice by Regulating Gut Microbiota to Restoring Th17/Treg Balance

Shuang Luo;Ruyan Wen

Journal of ethnopharmacology.

2018,231:39-49.

国外刊物

独立完成

3

Against NF-κB/TSLP signal pathway, catechin alleviates the inflammation in allergic rhinitis.

Zengfeng Pan

International Immunopharmacology.

2018,61:241-248.

国外刊物

独立完成

4

Effects of ceftriaxone induced intestinal dysbacteriosis on regulatory T cells validated by anaphylactic mice

Xia Luo; Zengfeng Pan

International Immunopharmacology.

2018,5(60):221-227.

国外刊物

独立完成

5

Identification of genes underlying the enhancement of immunity by a formula of lentinan, pachymaran and tremelia polysaccharides in immunosuppressive mice.

Xia Luo

Scientific reports,

2018 ,8(1):10082.

国外刊物

独立完成

6

Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice

Shuang Luo

International Immunopharmacology.

2018,59:269-275.

国外刊物

独立完成

7

Polysaccharides from Chinese herbal Lycium barbarum induced systemic and local immune responses in H22 tumor-bearing mice

Xiangliang Deng

Journal of immunology research.

2018: 3431782.

国外刊物

独立完成

8

Effects of Lycium barbarum polysaccharides with different molecular weights on function of RAW264.7 macrophages

Xiangliang Deng

Food and Agricultural Immunology,

2018:808-820

国外刊物

独立完成

9

Fraction From Lycium barbarum Polysaccharides Reduces Immunotoxicity and Enhances Antitumor Activity of Doxorubicin in Mice

Xiangliang Deng

Integrative Cancer Therapies

2018,17(3):860-866

国外刊物

独立完成

10

Protective roles and mechanisms of Dendrobium officinal polysaccharides on secondary liver injury in acute colitis

Jian Liang

International Journal of Biological Macromolecules.

2018 ,107(Pt B):2201-2210.

国外刊物

独立完成

11

Rhubarb Peony Decoction Ameliorates Ulcerative Colitis in Mice by Regulating Gut Microbiota to Restoring Th17/Treg Balance

Shuang Luo;Ruyan Wen

Journal of ethnopharmacology.

2018 ,231:39-49.

国外刊物

独立完成

12

Effects of ceftriaxone induced intestinal dysbacteriosis on regulatory T cells validated by anaphylactic mice

Xia Luo; Zengfeng Pan

International Immunopharmacology.

2018,5(60):221-227.

国外刊物

独立完成

13

Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice

Shuang Luo

International Immunopharmacology.

2018,59:269-275.

国外刊物

独立完成

14

Unravelling the novel protective effect of patchouli alcohol against Helicobacter pylori-induced gastritis: Insights into the molecular mechanism in vitro and in vivo

Da-wei Lian, Yi-fei Xu

Frontiers in pharmacology

2018 Oct

国外刊物

独立完成

15

A Novel Delivery System of Cyclovirobuxine D for Brain Targeting: Angiopep-Conjugated Polysorbate 80-Coated Liposomes via Intranasal Administration

Wei, HM

Journal of Biomedical Nanotechnology,

2018,14:1252-1262

国外刊物

独立完成

16

A Novel Delivery Method of Cyclovirobuxine D for Brain-Targeting: Chitosan Coated Nanoparticles Loading Cyclovirobuxine D by Intranasal Administration

Wei, HM

Journal of Nanoscience and Nanotechnology,

2018,18:5274-5282.

国外刊物

独立完成

17

Naringin ameliorates experimental diabetic renal fibrosis by inhibiting the ERK1/2 and JNK MAPK signaling pathways

Yan Yang

Journal of Functional Foods,

2018,53-62

国外刊物

独立完成

18

Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice

Xin-ChenWang

BioMed Research Internationa,

2018:3538763

国外刊物

独立完成

19

Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1

Lei Zhang

Front Pharmacol.

2018, 9:512

国外刊物

独立完成

20

Immature granulocytes: A novel biomarker of acute respiratory distress syndrome in patients with acute pancreatitis

Ying Huang

Journal of Critical Care

2018 Dec

国外刊物

合作完成-第二人

21

Lipocalin 2: a potential therapeutic target for breast cancer metastasis

Hu Chenxia

ONCOTARGETS AND THERAPY,

2018,11:8099-8106

国外刊物

合作完成-第一人

22

Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process

Li ,CL;Huang P,

J Enzyme Inhib Med Chem.

2018,33(1):1362-1375.

国外刊物

独立完成

23

the novel protective effect of patchouli alcohol against Helicobacter pylori-induced gastritis: Insights into the molecular mechanism in vitro and in vivo[J].

Da-wei Lian, Yi-fei Xu

Frontiers in pharmacology,

2018,9: 1347.

国外刊物

独立完成

24

Hypouricemic effect of 2, 5-dihydroxyacetophenone, a computational

screened bioactive compound from Ganoderma applanatum, on hyperuricemic mice

Danling Liang

International Journal of Molecular SciencesInt J Mol Sci,

2018,19(5):1394

国外刊物

合作完成-第一人

25

Anti-breast Cancer Enhancement of a Polysaccharide From Spore of

Ganoderma lucidum With Paclitaxel:Suppression on Tumor Metabolism With Gut Microbiota Reshaping

Dan Li; Jiyan Su

Frontiers in microbiology

2018 Dec

国外刊物

合作完成-第一人

26

Phloridzin alleviate colitis in mice by protecting the intestinal brush border and improving the expression of sodium glycogen transporter 1.

Ying-yu Lu; Jian Liang

Journal of Functional Foods,

2018,348-354

国外刊物

独立完成

27

Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.

Lian DW

Cell Physiol Biochem.

2018,50(4):1585-1600.

国外刊物

独立完成

28

Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway.

Lian DW

Phytomedicine.

2018,18:30535-X

国外刊物

独立完成

29

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide.

Lian DW

Mol Immunol.

2018,103:209-219.

国外刊物

独立完成

30

Zhen-wu-tang protects against podocyte injury in rats with IgA nephropathy via PPARγ/NF-κB pathway

Bihao Liu

Biomedicine & Pharmacotherapy,

2018,101:635–647

国外刊物

独立完成

31

MiR-145-5p inhibits proliferation and inflammatory responses

of RMC through regulating AKT/GSK pathway by targeting

CXCL16

Junbiao Wu; Yu He

J Cell Physiol.

2018,233(4):3648-3659

国外刊物

合作完成-第一人

32

Immunosuppressive effects of hydroxychloroquine and artemisinin combination therapy via the nuclear factor-κB signaling pathway in lupus nephritis mice

NIANG LIANG; YANCHUN ZHONG

EXPERIMENTAL AND THERAPEUTIC MEDICINE,

2018:2436-2442

国外刊物

合作完成-第一人

33

Comparison of different extraction methods for polysaccharides from Dendrobium officinale stem

He L, Yan X, Liang J,

CARBOHYDRATE POLYMERS,

2018:101-108

国外刊物

合作完成-第二人

34

Protective roles and mechanisms of polysaccharides from Dendrobium officinal on natural aging-induced premature ovarian failure

Wu YY

Biomed Pharmacother,

2018,101:953-960

国外刊物

合作完成-第一人

35

Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

Yuan X, Xu S

Scand J Med Sci Sports,

2018,28(5):1541-1551

国外刊物

合作完成-第一人

36

Phloridzin Alleviate Colitis In Mice By Protecting The Intestinal Brush Border And Improving The Expression Of Sodium Glycogen Transporter

Ying-yu Lu

Journal of Functional Foods,

2018:348-354

国外刊物

独立完成

37

Xiao-Shen-Formula, a Traditional Chinese Medicine, Improves Glomerular Hyper-filtration in Diabetic Nephropathy via Inhibiting Arginase Activation and Heparanase Expression

Xiaofei An

Front Physiol,

2018,9:1195

国外刊物

独立完成

38

Simultaneous qualitative and quantitative evaluation of Toddalia asiatica root by using HPLC‐DAD and UPLC‐QTOF‐MS/MS

Mingjuan Zhu; Pinqing Wei

Phytochemical Analysis,

2018,1-18

国外刊物

独立完成

39

Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation.

Mai, CT

MOLECULAR IMMUNOLOGY

2018,105:76-85.

国外刊物

独立完成

40

Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice

Yu, XT

PLoS One,

2018,13(3):e0194069.

国外刊物

合作完成-第二人

41

Antioxidative and hepatoprotective activities of the ethyl acetate fraction separated from the fruit of Livistona chinensis

Wang, CL

Journal of Traditional Chinese Medicine,

2018,38(04):523-534

国外刊物

合作完成-第一人

42

RNA-Sequencing Analysis Reveals Critical Roles of Hormone Metabolism and Signaling Transduction in Seed Germination of Andrographis paniculata https://doi.org/10.1007/s00344-018-9839-2

Jiayun Tong

Journal of Plant Growth Regulation

2018 Aug

国外刊物

独立完成

43

Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway

LiShijie

Carbohydrate Polymers

2018 APR

国外刊物

独立完成

44

Two heteropolysaccharides from Isaria cicadae Miquel differ in composition and potentially immunomodulatory activity

XuZhanchi

International Journal of Biological Macromolecules

2018 OCT

国外刊物

独立完成

45

An effective and recyclable deproteinization method for polysaccharide from oyster by magnetic chitosan microspheres

Song, Zhuoyue

Carbohydrate Polymers

2018 SEP

国外刊物

独立完成

46

Surface Imprinting on Spherical Macroporous Silica for Protein Recognition

Dandan Xu

Chem Lett,

2018,47(5):686-689.

国外刊物

独立完成

47

Facile synthesis of functionalized polymer microsphere

with three-dimensionally ordered macroporous structure

by a colloidal crystal templating method

Siqi Li

Colloid and Polymer Science,

2018,296(7):1267–1271

国外刊物

独立完成

48

A review on the hybrids of hydroxycinnamic acid as multi-targetdirected ligands against Alzheimer’s disease

Xiao Zhang

Bioorganic & Medicinal Chemistry

2018,26:543–550

国外刊物

合作完成-第二人

49

Synthesis and anti-glioblastoma effects of

artemisinin-isothiocyanate derivatives

Nyein, C.M.

RSC Adv.,

2018,8,40974–40983

国外刊物

独立完成

50

Lup-20(29)-en-3β,28-di-yl-nitrooxy acetate affects MCF-7 proliferation through the crosstalk between apoptosis and autophagy in mitochondria.

Xiaonin Yan

Cell Death & Disease

2018:241

国外刊物

合作完成-第二人

51

Novel betulin derivative induces anti-proliferative activity by G2/M phase cell cycle arrest and apoptosis in Huh7 cells

Zhenjia Zhuo

Oncology Letters

2018 Feb

国外刊物

合作完成-第一人

52

Antioxidant Mechanisms of Echinatin and Licochalcone A

Minshi Liang; Xican Li

Molecules.

2018 Dec

国外刊物

合作完成-第一人

53

Comparative Study of 1,1-Diphenyl-2-picryl-hydrazyl Radical (DPPH•) Scavenging Capacity of the Antioxidant Xanthones Family

Xican Li

ChemistrySelect,

2018,12

国外刊物

独立完成

54

Null B-Ring Improves the Antioxidant Levels of Flavonol: A Comparative Study between Galangin and 3,5,7-Trihydroxychromone

Xiaojian Ouyang; Xican Li

Molecules.

2018, 23(12), 3083

国外刊物

合作完成-第一人

55

Dual Effect of Glucuronidation of a Pyrogallol-type Phytophenol Antioxidant: A Comparison between Scutellarein and Scutellarin

Qianru Liu; Xican Li

Molecules.

2018, 23(12)

国外刊物

合作完成-第一人

56

Sanggenons C and D as Antioxidant Diels-Alder-Type Adducts Protecting Mesenchymal Stem Cells from Oxidative Stress: Evidence of the Steric Effect

Xican Li; Zhenxing Ren

Molecules.

2018, 23(10), 2610

国外刊物

合作完成-第一人

57

Structure-activity Relationship and Prediction of Electron-transfer Potential of Xanthones Series

Xican Li

ChemistryOpen

2018, 7, 730 –736

国外刊物

合作完成-第一人

58

pH Effect and Chemical Mechanisms of Antioxidant Higenamine.

Yulu Xie; Xican Li

Molecules.

2018, 23, 2176

国外刊物

合作完成-第一人

59

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO•) trapping Activity, Mechanisms, and Structure-activity of 16 phenolic Xanthones

Xican Li

Molecules.

2018, 23(7), 1692;

国外刊物

合作完成-第一人

60

E-Configuration Improves Antioxidant and Cytoprotective Capacities of Resveratrols

Jian Lin

Molecules.

2018, 23(7), 1790

国外刊物

独立完成

61

Antioxidant Structure–Activity Relationship Analysis of Five Dihydrochalcones

Xican Li

Molecules.

2018,23(5), 1162

国外刊物

独立完成

62

Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect

Xican Li

Molecules.

2018, 23(4), 973

国外刊物

独立完成

63

π -π Conjugation Enhances Oligostilbene’s Antioxidant Capacity: Evidence from α-Viniferin and Caraphenol A

Xican Li; Yulu Xie

Molecules.

2018, 23(3), 694

国外刊物

独立完成

64

Effect of Double Bond Position on 2-Phenyl-benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C

Xican Li; Hong Xie

Molecules.

2018, 23(4), 754

国外刊物

合作完成-第一人

65

Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry

Xican Li; Yulu Xie

Molecules.

2018, 23(2), 498

国外刊物

独立完成

66

Antioxidant and Cytoprotective Effects of Tibetan Tea and its Phenolic Components

Hong Xie; Xican Li

Molecules.

2018, 23(2), 179

国外刊物

独立完成

67

Antioxidant and Cytoprotective Effects of the Di-Ocaffeoylquinic Acid Family: The Mechanism, Structure–Activity Relationship, and Conformational Effect

Xican Li

Molecules.

2018, 23(1), 222

国外刊物

独立完成

68

Protective Mechanism of the Antioxidant Baicalein toward Hydroxyl Radical-Treated Bone Marrow-Derived Mesenchymal Stem Cells

Yage Tian ; Xican Li

Molecules.

2018, 23(1), 223

国外刊物

独立完成

69

Facile preparation of ordered macroporous carboxyl group functionalized plymer@SiO2 composites and their adsorption performance towards proteins

Lifang Ye

Journal of Inorganic and Organometallic Polymers and Materials,

2018, 28: 1011-1020

国外刊物

独立完成

70

Triterpenoids with antiplatelet aggregation activity from Ilex rotunda

Bao Yang; Jinping Zhu

Phytochemistry,

2018, 145: 179-186.

国外刊物

独立完成

71

Diterpenoids from Croton crassifolius include a novel skeleton possibly generated via an intramolecular [2+2]-photocycloaddition reaction

Maosong Qiu

Phytochemistry

2018, 145: 103-110.

国外刊物

独立完成

72

The therapeutic effect of Ilex pubescens extract on blood stasis model rats according to serum metabolomics

Di Cao

J Ethnopharmacol,

2018, 227: 18-28.

国外刊物

合作完成-第一人

73

A facile and selective approach to the qualitative and quantitative analysis of triterpenoids and phenylpropanoids by UPLC/Q-TOF-MS/MS for the quality control of Ilex rotunda

Bao Yang; Hui Li

J Pharm Biomed Anal.

2018, 157: 44-58.

国外刊物

独立完成

74

Identification of rotundic acid metabolites after oral administration to rats and comparison with the biotransformation by Syncephalastrum racemosum AS 3.264

Hi Li; Bao Yang

J Pharmaceut Biomed.

2018, 150: 406-412.

国外刊物

独立完成

75

Simultaneous Qualitative and Quantitative Analyses of Triterpenoids in Ilex pubescens by Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry

Di Cao; Qing Wang

Phytochem Anal.

2018, 29(2): 168-179.

国外刊物

独立完成

76

Rapid profiling and pharmacokinetic studies of multiple potential bioactive triterpenoids in rat plasma using UPLC/Q-TOF-MS/MS after oral administration of Ilicis Rotundae Cortex extract

Bao Yang; Hui Li

Fitoterapia.

2018, 129: 210-219.

国外刊物

独立完成

77

Diaporindenes A−D: Four Unusual 2,3-Dihydro 1H indene

Analogues with Anti-inflammatory Activities from the Mangrove

Endophytic Fungus Diaporthe sp. SYSU-HQ3

Hui Cui

J. Org. Chem.

2018, 83: 11804−11813

国外刊物

合作完成-第二人

78

Biospecific isolation and characterization of angiogenesis-promoting ingredients in Buyang Huanwu decoction using affinity chromatography on rat brain microvascular endothelial cells combined with solid-phase extraction, and HPLC-MS/MS

Liao, FY

Talanta,

2018,490-500

国外刊物

独立完成

79

Identification of active ingredients mediating anti-platelet aggregation effects of BuyangHuanwudecoction using a platelet binding assay, solid phase extraction, and HPLC-MS/MS

Liao, FY

Journal of Chromatography B,

2018:320-327

国外刊物

独立完成

80

Metal-Ion-Responsive Bionanocomposite for Selective and Reversible Enzyme Inhibition

Junqiu Zhai

翟筠秋

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2018 Nov

国外刊物

合作完成-第二人

81

Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation

王春怡,李艳

Frontiers in Pharmacology,

2018(9):345

国外刊物

合作完成-第一人

82

Protective effect of gigantol against hydrogen peroxide induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.

Chen H

Molecular Medicine Reports.

2018 Feb;17(2):3267-3273.

国外刊物

独立完成

83

Simultaneous identification and determination of flavonoids in Dendrobium officinale.

Zhou C

Chemistry Central Journal.

2018,12(1):40.

国外刊物

独立完成

84

UHPLC-ESI-MS Analysis of Purified Flavonoids Fraction from Stem of Dendrobium denneaum Paxt. and Its Preliminary Study in Inducing Apoptosis of HepG2 Cells.

Zhou C

Evid Based Complement Alternat Med.

2018,2018: 8936307.

国外刊物

独立完成

85

Transcriptome analysis reveals genes involved in flavonoid biosynthesis and accumulation in Dendrobium catenatum from different locations

Lei Z,

Scientific reports,

2018,8(1):6373.

国外刊物

独立完成

86

Isoviolanthin extracted from Dendrobium officinale reverses TGF-β1-mediated Epithelial–Mesenchymal Transition in Hepatocellular carcinoma cells via deactivating the TGF-β/Smad and PI3K/Akt/mTOR signaling pathways.

Xing S

International Journal of Molecular Sciences.

2018, 19, 1556.

国外刊物

合作完成-第二人

87

Rosmarinic acid protects on rat bone marrow mesenchymal stem cells from hydrogen peroxide-induced apoptosis.

Lin LZ

Journal of Asian Natural Products Research.

2018,20(6):570-580.

国外刊物

独立完成

88

Structural Characterization of Polysaccharides from Dendrobium officinale and Their Effects on Apoptosis of HeLa Cell Line.

Yu W

Molecules.

2018,23(10). pii: E2484.

国外刊物

独立完成

89

Physicochemical properties of polysaccharides from Dendrobium officinale by fractional precipitation and their preliminary antioxidant and anti-HepG2 cells activities in vitro.

Xing S

Chemistry Central Journal.

2018,12(1):103.

国外刊物

合作完成-第二人

90

Metabolomics insights into the modulatory effects of long-term compound polysaccharide intake in high-fat diet-induced obese rats

ChenMY(陈明毅)

Nutrition & Metabolism.

2018, 15(8). DOI 10.1186/s12986-018-0246-2.

国外刊物

合作完成-第二人

91

Metabonomic strategy for the detection of metabolic effects of probiotics combined with prebiotic supplementation in weaned rats.

WangMX(汪梦霞)

RSC Adv

2018, 8:5042 -5057

国外刊物

合作完成-第二人

92

The effect of probiotics and polysaccharides on the gut microbiota composition and function of weaned rats.

WangMX(汪梦霞)

Food Function

2018, 9, 1864-1877

国外刊物

合作完成-第二人

93

Association between metabolic profile and microbiomic changes in rats with functional dyspepsia

LuoL(罗良)

RSC Adv.,

2018,8:20166-20181

国外刊物

独立完成

94

Beneficial changes of gut microbiota and metabolism in weaned rats with Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 supplementation

WangMX(汪梦霞)

Journal of functional foods.

2018, 48, 252-265

国外刊物

合作完成-第二人

95

Huang-Lian-Jie-Du-Decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation

ChenMY(陈明毅)

Frontiers in Microbiology

2018,9,2380

国外刊物

合作完成-第二人

96

Gastric retention pellets of edaravone with enhanced oral bioavailability:

Absorption mechanism, development, and in vitro/in vivo evaluation

Qingguo Li (李庆国)

European Journal of Pharmaceutical Sciences.

2018,119:62-69

国外刊物

独立完成

97

Genetic diversity, population structure and identification

of Dendrobium cultivars with high polysaccharide contents

using SCoT, SCAR and nested PCR markers

Qingguo Li (李庆国)

Genet Resour Crop Evol,2018

2018, Oct

国外刊物

独立完成

98

Solubility of Azoxystrobin and Benflumetol in Compressed CO2 Measured by the Static Precise Mass Measuring Method

Qingguo Li (李庆国)

Journal of Chemical and Engineering Data

2018 Dec

国外刊物

合作完成-第一人

99

Purification and functional characterization of the C-terminal domain of the β-actin-binding protein AIM1 in vitro

Fang Wu (吴芳)

MOLECULES,

2018,23(12).

国外刊物

独立完成

100

Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein

Lou, YM (楼艳梅); Guo, ZZ (郭珍珍)

Journal of Ethnopharmacology,

2018, 228: 82-91.

国外刊物

独立完成

101

A systematic review of pharmacokinetic studies on herbal drug Fuzi: implications for Fuzi as personalized medicine

Wu, JJ (吴锦俊)

Phytomedicine,

2018,44:187-203

国外刊物

独立完成

102

Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway

Wu, JJ (吴锦俊)

Phytomedicine,

2018,44:87-97

国外刊物

合作完成-第一人

103

Pubescenosides E–K, seven new triterpenoid saponins from the roots of Ilex pubescens and their anti-inflammatory activity

Xiaoxu Qiao,乔晓旭

molecules,

2018, 23, 1426.

国外刊物

独立完成

104

Evodiamine, A Novel NOTCH3 Methylation Stimulator, Significantly Suppressed Lung Carcinogenesis In Vitro and In Vivo

苏桃,阳霞

Frontiers in Pharmacology.

2018,1;9:434

国外刊物

合作完成-第一人

105

Simultaneous determination of tilianin and its metabolites in mice using ultra-high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

王丽萍

Biomedical Chromatography,

2018,32(4)

国外刊物

合作完成-第一人

106

Senescence inducer shikonin ROS-dependently suppressed lung cancer progression

郑宏明,黄秋菊

Frontiers in pharmacology,

2018,23;9:519

国外刊物

合作完成-第一人

107

Tissue distribution and gender-specific protein expression of cytochrome P450 in five mouse genotypes with a background of FVB

陈佳美

Pharmaceutical research,

2018,35(6):114

国外刊物

合作完成-第一人

108

Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4

吕世栋

Oncogene,

2018,37(10):1354-1368

国外刊物

合作完成-第二人

109

DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment.

卢琳琳,王莹

Pharmacological Research,

2018,129:318-328

国外刊物

合作完成-第一人

110

Camptosorus sibiricus Rupr Aqueous Extract Prevents Lung Tumorigenesis via Dual Effects against ROS and DNA Damage

何书柜,欧日兰

Journal of Ethnopharmacology,

2018,28,220:44-56.

国外刊物

合作完成-第一人

111

Age‐related changes in hepatic expression and activity of drug metabolizing enzymes in male wild‐type and breast cancer resistance protein knockout mice

郑海辉,王丽萍

Biopharmaceutics & Drug Disposition,

2018,1–10

国外刊物

合作完成-第一人

112

The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy

廖国超

european journal of medicinal chemistry,

2018,5;159:1-9

国外刊物

独立完成

113

Interplay of Efflux Transporters with Glucuronidation and Its Impact Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol

李玉环,卢琳琳

Molecular Pharmaceutics.

2018,Nov

国外刊物

合作完成-第一人